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Medicinal uses

Uses supported by clinical data

The principal use of Rhizoma Curcumae Longae is for the treatment of acid,flatulent, or atonic dyspepsia.

Uses described in pharmacopoeias and in traditional systems of medicine

Treatment of peptic ulcers, and pain and inflammation due to rheumatoid arthritis and of amenorrhoea, dysmenorrhoea, diarrhoea,epilepsy, pain, and skin diseases.

Uses described in folk medicine, not supported by experimental or clinical data

The treatment of asthma, boils, bruises, coughs, dizziness, epilepsy,haemorrhages, insect bites, jaundice, ringworm, urinary calculi, and slow lactation.

 

Pharmacology

Experimental pharmacology

Anti-inflammatory activity

The anti-inflammatory activity of Rhizoma Curcumae Longae has been demonstrated in animal models. Intraperitoneal administration of the drug in rats effectively reduced both acute and chronic inflammation in carrageenan induced paw oedema, the granuloma pouch test, and the cotton pellet granuloma test.


The effectiveness of the drug in rats was reported to be similar to that of hydrocortisone acetate or indometacin in experimentally induced inflammation. Oral administration of turmeric juice or powder did not produce an anti-inflammatory effect; only intraperitoneal injection was effective.


The volatile oil has exhibited anti-inflammatory activity in rats against adjuvant-induced arthritis, carrageenin-induced paw oedema, and yaluronidase-induced inflammation. The anti-inflammatory activity appears to be mediated through the inhibition of the enzymes trypsin and hyaluronidase. Curcumin and its derivatives are the active anti-inflammatory constituents of the drug. After intraperitoneal administration, curcumin and sodium curcuminate exhibited strong anti-inflammatory activity in the carrageenin-induced oedema test in rats and mice.


Curcumin was also found to be effective after oral administration in the acute carrageenin-induced oedema test in mice and rats. The anti-inflammatory activity of curcumin may be due to its ability to scavenge oxygen radicals, which have been implicated in the inflammation process. Furthermore, intraperitoneal injection of a polysaccharide fraction, isolated from the drug, increased phagocytosis capacity in mice in the clearance of colloidal carbon test .


Activity against peptic ulcer and dyspepsia

Oral administration to rabbits of water or methanol extracts of the drug significantly decreased gastric secretion and increased the mucin contents of gastric juice. Intragastric administration of an ethanol extract of the drug to rats effectively inhibited gastric secretion and protected the gastroduodenal mucosa against injuries caused by pyloric ligation, hypothermic-restraint stress, indometacin, reserpine, and mercaptamine administration, and cytodestructive agents such as 80% methanol, 0.6mol/l hydrochloric acid, 0.2mol/l sodium hydroxide and 25% sodium chloride. The drug stimulated the production of gastric wall mucus, and it restored non-protein sulfides in rats.


Curcumin, one of the anti-inflammatory constituents of the drug, has beenshown to prevent and ameliorate experimentally induced gastric lesions in animal models by stimulation of mucin production. However, there are conflicting reports regarding the protective action of curcumin against histamine-induced gastric ulceration in guinea-pigs. Moreover, both intraperitoneal and oral administration of curcumin (100 mg/kg) have been reported to induce gastric ulceration in rats.


Non-specific inhibition of smooth muscle contractions in isolated guinea-pig ileum by sodium curcuminate has been reported.


The effect of curcumin on intestinal gas formation has been demonstrated in vitro and in vivo. Addition of curcumin to Clostridium perfringens of intestinal origin in vitro and to a chickpea flour diet fed to rats led to a gradual reduction in gas formation.


Both the essential oil and sodium curcuminate increase bile secretion after intravenous administration to dogs. In addition, gall-bladder muscles were stimulated.


Clinical pharmacology

Oral administration of the drug to 116 patients with acid dyspepsia, flatulent dyspepsia, or atonic dyspepsia in a randomized, double-blind study resulted in a statistically significant response in the patients receiving the drug. The patients received 500 mg of the powdered drug four times daily for 7 days.


Two other clinical trials which measured the effect of the drug on peptic ulcers showed that oral administration of the drug promoted ulcer healing and decreased the abdominal pain involved. Two clinical studies have shown that curcumin is an effective anti-inflammatory drug.


A short-term (2 weeks) double-blind, crossover study of 18 patients with rheumatoid arthritis showed that patients receiving either curcumin (1200 mg/day) or phenylbutazone (30 mg/day) had significant improvement in morning stiffness, walking time and joint swelling.


In the second study, the effectiveness of curcumin and phenylbutazone on postoperative inflammation was investigated in a double-blind study. Both drugs produced a better anti-inflammatory response than a placebo, but the Rhizoma Curcumae Longae degree of inflammation in the patients varied greatly and was not evenly distributed among the three groups.

Ref - WHO monograph on selected medicinal plants


WILEY | Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial

Scope | We previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats. This study was to investigate whether curcuminoids have beneficial effects on type 2 diabetic patients, and its possible mechanisms.

Methods and results | Overweight/obese type 2 diabetic patients (BMI ≥ 24.0; fasting blood glucose ≥ 7.0 mmol/L or postprandial blood glucose ≥11.1 mmol/L) were randomly assigned to curcuminoids (300 mg/day) or placebo for 3 months. Bodyweight, glycosylated hemoglobin A1c (HbA1c,%), serum fasting glucose, FFAs, lipids, and lipoprotein lipase (LPL) were determined. A total of 100 patients (curcuminoids, n = 50; placebo, n = 50) completed the trial. Curcuminoids supplementation significantly decreased fasting blood glucose (p < 0.01), HbA1c (p = 0.031), and insulin resistance index (HOMA-IR) (p < 0.01) in type 2 diabetic patients. Curcuminoids also led to a significant decrease in serum total FFAs (p < 0.01), triglycerides (P = 0.018), an increase in LPL activity (p < 0.01).

Conclusion | These findings suggest a glucose-lowering effect of curcuminoids in type 2 diabetes, which is partially due to decrease in serum FFAs, which may result from promoting fatty acid oxidation and utilization.

 

 

Tags: cucurma, cucurmin, dushyantdhari, turmeric

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Replies to This Discussion

The CDC reports that mortality doubled from gastrointestinal infections in the United States between the years 1997 and 2007, rising to 17,000 deaths per year from 7,000 a year, with a majority of those affected over age 65.

It appears a virulent and resistant strain Clostridium difficile bacteria caused the majority of deaths, while a highly contagious norovirus found on cruise ships and in prisons, dormitories and hospitals caused many other deaths.

The HWC members have had numerous discussions about MRSA and resistant bacteria from the over use of antibacterial soaps and antibiotics. We, as a people, with our concern for cleanliness and sterilizing our environment and fear of contacting and contracting disease have caused our own problems and demise.

Instead of learning to live in harmony with our surroundings, we have tried to make everything antiseptic and in the process have forced the bacteria to go into survival mode and overcome all the attacks from the chemicals mankind produces. We can't win such a war.

The CDC Emerging Infectious Diseases | Clostridium difficile, an anaerobic, gram-positive bacillus causes considerable symptoms, such as diarrhea, colitis, and septicemia, which may all lead to death.   The elderly aged 65 and older harbor the most risk from succumbing to the C. difficile–associated disease (CDAD) and has been associated with there living quarters and the over use of antimicrobial medications and cleaners. We might even say the CDAD has risen to epidemic proportions.

  • "Death rates associated with C. difficile were reported to be increasing from 1999 to 2002 in the United States and from 2001 to 2005 in England and Wales . However, no trend analysis was conducted to evaluate the rate of increase. We incorporated mortality data for the United States through the year 2004 to conduct trend analyses of CDAD-related deaths and to examine demographic characteristics and coexisting conditions reported in deaths from C. difficile infection."

However, with that said, proper sanitation practices, every primitive people know to keep their toilet facilities away from the places they carry on daily activities of eating, sleeping, working and entertainment. What has happened in modern society that people do not keep these stations separate, that people do not wash as a ritual before and after handling food products and having a meal? This basic knowledge must now be taught and practiced as not to infect ourselves from our own feces.

Further information on NYT

Add extra turmeric, ginger and parsley to nightly winter vegetable soup to stay warm and well.

Today its used in almost every cure, would you know how much is needed on a daily basis?

-Very Useful medicine as an Anti-oxident .
-Very useful in so many chronic diseses .

-Should be given in Mother Tincture form .

some more informations : Curcuma longa : http://ccrhindia.org/pdf/ijrh/5(1)/4.pdf

Curcumin to protect from fluoride toxicity 

Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

The natural spice turmeric (curcumin) is a protective agent against various health effects associated with fluoride toxicity. The researchers from the Department of Zoology, University College of Science, M.L. Sukhadia University, Udaipur, India, have spent the past decade investigating the effects fluoride has on neurology, and in particular the cells of the hippocampus and cerebral cortex.

  • "...a daily single dose of 120 ppm F result in highly significant increases in the LPO [lipid peroxidation, i.e. brain rancidity] as well as neurodegenerative changes in neuron cell bodies of selected hippocampal regions. Supplementation with curcumin significantly reduce the toxic effect of F to near normal level by augmenting the antioxidant defense through its scavenging property and provide an evidence of having therapeutic role against oxidative stress mediated neurodegeneration.”

Sources: 
Bhatnagar M, Rao P, Saxena A, Bhatnagar R, Meena P, Barbar S. Biochemical changes in brain and other tissues of young adult female mice from fluoride in their drinking water. Fluoride. 2006;39:280–4. [Ref list]

Bhatnagar M, Sukhwal P, Suhalka P, Jain A, Joshi C, Sharma D. Effects of fluoride in drinking water on NADPH-diaphorase neurons in the forebrain of mice: A possible mechanism of fluoride neurotoxicity. Fluoride. 2011;44:195–9. [Ref list]

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