Creating Waves of Awareness
The principal use of Rhizoma Curcumae Longae is for the treatment of acid,flatulent, or atonic dyspepsia.
Uses described in pharmacopoeias and in traditional systems of medicine
Treatment of peptic ulcers, and pain and inflammation due to rheumatoid arthritis and of amenorrhoea, dysmenorrhoea, diarrhoea,epilepsy, pain, and skin diseases.
Uses described in folk medicine, not supported by experimental or clinical data
The treatment of asthma, boils, bruises, coughs, dizziness, epilepsy,haemorrhages, insect bites, jaundice, ringworm, urinary calculi, and slow lactation.
The anti-inflammatory activity of Rhizoma Curcumae Longae has been demonstrated in animal models. Intraperitoneal administration of the drug in rats effectively reduced both acute and chronic inflammation in carrageenan induced paw oedema, the granuloma pouch test, and the cotton pellet granuloma test.
The effectiveness of the drug in rats was reported to be similar to that of hydrocortisone acetate or indometacin in experimentally induced inflammation. Oral administration of turmeric juice or powder did not produce an anti-inflammatory effect; only intraperitoneal injection was effective.
The volatile oil has exhibited anti-inflammatory activity in rats against adjuvant-induced arthritis, carrageenin-induced paw oedema, and yaluronidase-induced inflammation. The anti-inflammatory activity appears to be mediated through the inhibition of the enzymes trypsin and hyaluronidase. Curcumin and its derivatives are the active anti-inflammatory constituents of the drug. After intraperitoneal administration, curcumin and sodium curcuminate exhibited strong anti-inflammatory activity in the carrageenin-induced oedema test in rats and mice.
Curcumin was also found to be effective after oral administration in the acute carrageenin-induced oedema test in mice and rats. The anti-inflammatory activity of curcumin may be due to its ability to scavenge oxygen radicals, which have been implicated in the inflammation process. Furthermore, intraperitoneal injection of a polysaccharide fraction, isolated from the drug, increased phagocytosis capacity in mice in the clearance of colloidal carbon test .
Activity against peptic ulcer and dyspepsia
Oral administration to rabbits of water or methanol extracts of the drug significantly decreased gastric secretion and increased the mucin contents of gastric juice. Intragastric administration of an ethanol extract of the drug to rats effectively inhibited gastric secretion and protected the gastroduodenal mucosa against injuries caused by pyloric ligation, hypothermic-restraint stress, indometacin, reserpine, and mercaptamine administration, and cytodestructive agents such as 80% methanol, 0.6mol/l hydrochloric acid, 0.2mol/l sodium hydroxide and 25% sodium chloride. The drug stimulated the production of gastric wall mucus, and it restored non-protein sulfides in rats.
Curcumin, one of the anti-inflammatory constituents of the drug, has beenshown to prevent and ameliorate experimentally induced gastric lesions in animal models by stimulation of mucin production. However, there are conflicting reports regarding the protective action of curcumin against histamine-induced gastric ulceration in guinea-pigs. Moreover, both intraperitoneal and oral administration of curcumin (100 mg/kg) have been reported to induce gastric ulceration in rats.
Non-specific inhibition of smooth muscle contractions in isolated guinea-pig ileum by sodium curcuminate has been reported.
The effect of curcumin on intestinal gas formation has been demonstrated in vitro and in vivo. Addition of curcumin to Clostridium perfringens of intestinal origin in vitro and to a chickpea flour diet fed to rats led to a gradual reduction in gas formation.
Both the essential oil and sodium curcuminate increase bile secretion after intravenous administration to dogs. In addition, gall-bladder muscles were stimulated.
Oral administration of the drug to 116 patients with acid dyspepsia, flatulent dyspepsia, or atonic dyspepsia in a randomized, double-blind study resulted in a statistically significant response in the patients receiving the drug. The patients received 500 mg of the powdered drug four times daily for 7 days.
Two other clinical trials which measured the effect of the drug on peptic ulcers showed that oral administration of the drug promoted ulcer healing and decreased the abdominal pain involved. Two clinical studies have shown that curcumin is an effective anti-inflammatory drug.
A short-term (2 weeks) double-blind, crossover study of 18 patients with rheumatoid arthritis showed that patients receiving either curcumin (1200 mg/day) or phenylbutazone (30 mg/day) had significant improvement in morning stiffness, walking time and joint swelling.
In the second study, the effectiveness of curcumin and phenylbutazone on postoperative inflammation was investigated in a double-blind study. Both drugs produced a better anti-inflammatory response than a placebo, but the Rhizoma Curcumae Longae degree of inflammation in the patients varied greatly and was not evenly distributed among the three groups.
Ref - WHO monograph on selected medicinal plants
WILEY | Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: a double-blind, placebo-controlled trial
Scope | We previously found that curcuminoids decreased blood glucose and improved insulin resistance by reducing serum free fatty acids (FFAs) and increasing fatty acid oxidation in skeletal muscle of diabetic rats. This study was to investigate whether curcuminoids have beneficial effects on type 2 diabetic patients, and its possible mechanisms.
Methods and results | Overweight/obese type 2 diabetic patients (BMI ≥ 24.0; fasting blood glucose ≥ 7.0 mmol/L or postprandial blood glucose ≥11.1 mmol/L) were randomly assigned to curcuminoids (300 mg/day) or placebo for 3 months. Bodyweight, glycosylated hemoglobin A1c (HbA1c,%), serum fasting glucose, FFAs, lipids, and lipoprotein lipase (LPL) were determined. A total of 100 patients (curcuminoids, n = 50; placebo, n = 50) completed the trial. Curcuminoids supplementation significantly decreased fasting blood glucose (p < 0.01), HbA1c (p = 0.031), and insulin resistance index (HOMA-IR) (p < 0.01) in type 2 diabetic patients. Curcuminoids also led to a significant decrease in serum total FFAs (p < 0.01), triglycerides (P = 0.018), an increase in LPL activity (p < 0.01).
Conclusion | These findings suggest a glucose-lowering effect of curcuminoids in type 2 diabetes, which is partially due to decrease in serum FFAs, which may result from promoting fatty acid oxidation and utilization.
The CDC reports that mortality doubled from gastrointestinal infections in the United States between the years 1997 and 2007, rising to 17,000 deaths per year from 7,000 a year, with a majority of those affected over age 65.
It appears a virulent and resistant strain Clostridium difficile bacteria caused the majority of deaths, while a highly contagious norovirus found on cruise ships and in prisons, dormitories and hospitals caused many other deaths.
The HWC members have had numerous discussions about MRSA and resistant bacteria from the over use of antibacterial soaps and antibiotics. We, as a people, with our concern for cleanliness and sterilizing our environment and fear of contacting and contracting disease have caused our own problems and demise.
Instead of learning to live in harmony with our surroundings, we have tried to make everything antiseptic and in the process have forced the bacteria to go into survival mode and overcome all the attacks from the chemicals mankind produces. We can't win such a war.
The CDC Emerging Infectious Diseases | Clostridium difficile, an anaerobic, gram-positive bacillus causes considerable symptoms, such as diarrhea, colitis, and septicemia, which may all lead to death. The elderly aged 65 and older harbor the most risk from succumbing to the C. difficile–associated disease (CDAD) and has been associated with there living quarters and the over use of antimicrobial medications and cleaners. We might even say the CDAD has risen to epidemic proportions.
However, with that said, proper sanitation practices, every primitive people know to keep their toilet facilities away from the places they carry on daily activities of eating, sleeping, working and entertainment. What has happened in modern society that people do not keep these stations separate, that people do not wash as a ritual before and after handling food products and having a meal? This basic knowledge must now be taught and practiced as not to infect ourselves from our own feces.
Add extra turmeric, ginger and parsley to nightly winter vegetable soup to stay warm and well.