On 10 September 2014, the United States of America informed the Pan American Health Organization/World Health Organization (PAHO/WHO) about an outbreak of severe respiratory illness associated with Enterovirus D68 (EV-D68). As of 16 September 2014, 130 laboratory-confirmed cases of EV-D68 have been reported in 12 US states – Alabama, Colorado, Illinois, Indiana, Iowa, Kansas, Kentucky, Louisiana, Missouri, New York, Oklahoma, and Pennsylvania. Investigations into suspected clusters in many other states are ongoing.
EV-D68 is identified using molecular techniques at a limited number of laboratories in the USA. Enterovirus infections, including EV-D68, are not nationally notifiable, but laboratory detections of enterovirus and parechovirus types are reported voluntarily to the National Enterovirus Surveillance System, which is managed by the US Centers for Disease Control and Prevention.